In vivo, treatment with iZAK2 attenuated the SLE symptoms in a lupus-like inflammation model induced in BM12 mice transferred with Trex1–/–CD4+ T cells, as measured by anti-dsDNA/ssDNA/histone IgG or IgM and ANA in the serum (Fig. 7F), the frequencies of Tfh, GC B and plasma cells in the spleen ( Fig. S3B and S3C), and the IgG deposition in the kidney (Fig. 7G). This evidence concerns the gene CD4 and systemic lupus erythematosus.