Nonetheless, this study also highlights that chronic stress can promote mutated Kirsten rat sarcoma viral oncogene homologue (Kras)-induced pancreatic tumorigenesis by increasing circulating catecholamines and stimulating Adrb2-dependent pancreatic epithelial growth, as well as upregulating NGF secretion to increase sympathetic innervation and local NE accumulation, generating an Adrb2-neurotrophin feedforward loop to promote pancreatic cancer [109]. Here, ADRB2 is linked to familial pancreatic carcinoma.