While mice lacking RIPK1 die perinatally, mice expressing kinase-inactive mutants of RIPK1, such as RIPK1-K45A mutant or RIPK1-D138N mutant, are viable and highly resistant to TNFα-induced cell death and inflammatory conditions associated with chronic infection, sepsis, degenerative conditions, or other types of tissue injury [38–40]. Here, RIPK1 is linked to Sepsis.