Treatment of RIPK1 inhibitor in AngII-induced renal injury and fibrosis mouse model prevents renal tubular epithelial cells from necroptosis and attenuates interstitial lesion, suggesting an important role of RIPK1 kinase in the development of renal fibrosis and CKD in AngII-induced renal injury and fibrosis mouse model [170]. The gene discussed is AGT; the disease is fibrosis.