XDH and metabolic dysfunction-associated steatotic liver disease: Interestingly, the early stage of NAFLD, hepatosteatosis, is often accompanied by enhanced fatty acid (FA) oxidation (FAO) with HU [19, 20], while XOR can also promote activation of the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome, which predominantly mediates non-alcoholic hepatotitis (NASH) [21, 22].