Here, we analyzed the following metabolic risk factors: fasting plasma glucose (FPG), 2-h post-load plasma glucose (2h-PG), hemoglobin A1c (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), diabetes, systolic and diastolic blood pressure (SBP/DBP), hypertension, triglyceride (TG), TC, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL cholesterol (non-HDL-C), Lipoprotein(a) (Lp(a)), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), dyslipidemia, and body mass index (BMI) (Fig. 1; Supplementary Table S1). The gene discussed is INS; the disease is diabetes mellitus.