Overexpression of MEG3 in primary hepatocytes protected cells from steatosis by reducing FFA accumulation via the redirection of EZH2 to ubiquitination-mediated proteolysis, consequently reducing the binding of EZH2 and H3K27me3 to the promoter of sirtuin 6 (SIRT6), a gene previously shown to be protective against MASLD54 55 (figure 1). Here, SIRT6 is linked to steatosis.