H19 and hepatocellular carcinoma: H19, a lncRNA that spans 2.3kb and is situated at 11p15.5, is exclusively expressed from the maternal allele; H19 is detected in the nucleus and the cytoplasm but primarily functions in the cytoplasm.28 29 H19 expression is regulated by c-MYC, which binds to E-boxes near the imprinting control region, enabling histone acetylation and the initiation of H19 gene transcription in HCC cells.30