SREBF1 and fatty liver disease: Inhibition of Notch signalling was found to ameliorate hepatic steatosis by inhibiting mTORC1, a protein previously shown to be a protective regulator of lipid homoeostasis in an S6K-dependent and protein kinase B (AKT)-independent manner,38 and augmenting SREBP1c-mediated lipogenesis39 (figure 1).