Research combining Hi-C and RNA-seq reveal that enhancer-promoter loops containing colorectal cancer-specific enhancers are involved in changes in 50% of TADs and interact with 152 highly expressed genes, including ITGB4, RECQL4, MSLN, and GDF15, in colorectal cancer cells compared to normal colon cells, which may play an important role in the progression of colorectal cancer [156]. Here, ITGB4 is linked to colorectal cancer.