Indeed, Insoluble aggregation of proteins is a typical pathological feature of neurodegenerative disorders, such as alpha-synuclein (SNCA) aggregates in Parkinson’s disease, TAU aggregates in Alzheimer’s disease, huntingtin (HTT) aggregation in Huntington’s disease, and granular protein aggregation in stress amyotrophic lateral sclerosis and frontotemporal dementia (FTD). This evidence concerns the gene HTT and Alzheimer disease.