Further metabolic transcription analysis identified that FOXP3-overexpressing CD8+ TIL cells enrich the metabolic pathways like glycolysis, fatty acid metabolism, and OXPHOS, indicating that those FOXP3-engineered CD8+ T cells resemble the metabolic feature of tumor-infiltrating Treg cells and confer a survival advantage in a harsh TME [107]. The gene discussed is FOXP3; the disease is neoplasm.