SCAP and colon adenocarcinoma: It has been reported that the viability and TCR-induced functional maturation of Treg cells rely on the upregulation of SREBP signaling within the TME, as deficiency of SREBP-cleavage-activating protein (SCAP) (a protein involved in cholesterol biosynthesis) or FASN in Treg cells retards the tumor growth of MC38 colon adenocarcinoma and B16 melanoma tumors [16].