For instance, the NASH-specific down-regulated lncRNA XLOC-041531 can bind with miR-5114 or miR-574-5p to regulate Axl; bind with miR-5114 or miR-193b-3p to regulate Aph1c; and bind with miR-532-5p or miR-193b-3p to regulate Adamtsl3 (Fig. 8n). This evidence concerns the gene ADAMTSL3 and metabolic dysfunction-associated steatohepatitis.