GDF3 and metabolic dysfunction-associated steatotic liver disease: Furthermore, we constructed the area under a receiver-operating characteristic curve (AUROC) for plasma GDF3 concentrations and found that it exhibited a high accuracy for distinguishing patients with NASH from the total patients with NAFLD (AUROC = 0.90; 95% confidence interval: 0.85−0.95, P < 0.001) (Fig. 3i).