The top 5 up-regulated genes in NASH mice included those encoding for Trem2, Lcn2, Ephb2, Mmp12, and Sprr1a, while the top 5 down-regulated genes were those encoding for Sqle, Serpina1e, Idi1, Adgrf1, and Mup16 (Fig. 1d). Here, SPRR1A is linked to metabolic dysfunction-associated steatohepatitis.