NLRP3 is a component of the inflammasome pathway that regulates maturation of the inflammatory cytokines interleukin (IL)-1b and IL-18, and in the absence of REV-ERBα, dysregulated expression of Nlrp3 leads to increased IL-1b and IL-18 and susceptibility to fulminant hepatitis [28]. The gene discussed is IL1B; the disease is Fulminant hepatitis.