NF-κB is a transcriptional master regulator of the inflammatory response, and the Rela gene, which encodes the NF-κB subunit p65, was also shown to be directly repressed by REV-ERBα, such that mice with REV-ERBα deletion succumbed more readily to dextran sulfate sodium-induced colitis [29]. The gene discussed is NFKB1; the disease is colitis.