PGK1 and neoplasm: The moonlighting protein kinase activity of PGK1 can autophosphorylate PGK1 at Y324 and autoactivate PGK1, and the deficiency or mutation of PTEN, which functions as a protein phosphatase to dephosphorylate PGK1 pY324, in tumor cells enhances the PGK1-promoted Warburg effect [7].