Next, we sought to investigate migrasome formation in other senescent hMSC models and turned to the Hutchinson-Gilford progeria syndrome (HGPS) model, in which premature aging characteristics are caused by a dominant-negative mutation in LMNA (c.1824 C > T; p.G608G) (Fig. 1G and Supplementary Fig. S1E) [30–32]. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.