While histone modifications have been extensively studied in high-grade gliomas (HGG), such as proteomics combined with other multi-omics revealing the central role of PTPN11 signaling in high-grade gliomas (Lowe et al., 2019a), and histone H3 mutations promoting diffuse glioma development through chromatin dysregulation (Lowe et al., 2019b), related research in LGG remains relatively scarce. Here, PTPN11 is linked to central nervous system cancer.