Subsequently, we performed a prognostic analysis across these 33 cancers, identifying CSNK1E as a risk factor in 12 cancer types, including adrenocortical carcinoma (ACC), BLCA, HNSC, KIRC, lower grade glioma (LGG), LIHC, LUAD, mesothelioma (MESO), ovarian cancer (OV), sarcoma (SARC), skin cutaneous melanoma (SKCM), and uveal melanoma (UVM), with a correlation to poorer prognosis (p < 0.05, log10(HR) > 0, Figure 5B). This evidence concerns the gene CSNK1E and central nervous system cancer.