A recent study by Li et al. also reported that roxadustat (FG-4592) pretreatment inhibited ferroptosis in renal tubular epithelial cells through the Akt/GSK3β/Nrf2 signaling pathway in folic acid-induced AKI, thereby improving renal injury and renal fibrosis (Li X. et al., 2020). This evidence concerns the gene AKT1 and renal fibrosis.