In a study based on bioinformatics to explore new ferroptosis gene biomarkers in diabetic nephropathy (DN), it was found that the six ferroptosis-related biomarkers (ALOX5, CCL5, KRT19, LCN2, LTF, and RRM2) identified were closely related to the immune status of DN and may play an important role in the pathogenesis of DN (Huang and Yuan, 2024). This evidence concerns the gene RRM2 and liver dysplastic nodule.