It was shown NFκB pathway induction not only causes resistance to apoptosis (Zheng et al., 2017), but is also associated with chemoresistance in a variety of cancers (He et al., 2021; Zhai et al., 2019; Zhao et al., 2018), although this has not been reported in lung cancer brain metastatic cells. The gene discussed is NFKB1; the disease is lung cancer.