A second independent association was observed at rs62206790 (OR = 2.780, 95% CI 1.864–4.146, p = 2.02 × 10−7) in MLLT10P1. SNPs in FRG1HP (rs879176184) (OR = 2.724, 95% CI 1.822–4.073, p = 4.30 × 10−7) and IGBP1P5 (rs13115019) (OR = 2.437, 95% CI 1.702–3.488, p = 5.80 × 10−7) were also increased risk for PFO. Here, FRG1HP is linked to Patent foramen ovale.