The homologous functional gene of DUX4L35, DUX4, is associated with several diseases, including skeletal muscle atrophy and human end-stage cardiomyopathy (Mocciaro et al., 2021), while it is epigenetically silenced in most somatic tissues of healthy humans (Movassagh et al., 2011), and its expression could not be detected in the single-cell gene expression datasets. Here, DUX4 is linked to muscular atrophy.