The high expression of histone deacetylase is involved in different phenotypes of heart disease, including myocardial hypertrophy, myocardial fibrosis, ventricular dilatation, arrhythmia, cardiac dysfunction, etc. (Jin et al., 2023) It has been reported that silencing CNOT2 could affected cardiac chamber size and contractility, which also proved that CCR4-NOT complex played crucial role in heart development and function (Elmen et al., 2020). This evidence concerns the gene CNOT2 and Ventriculomegaly.