Previous studies have demonstrated that oleic acid, a major component of Brucea javanica oil, can inhibit the proliferation and induce apoptosis and autophagy in oral squamous cell carcinoma cell lines (8); SOD2 is highly expressed in oral squamous cell carcinoma tissues (9); and the key Glycolysis enzymes HK2 and PKM2 can enhance the invasive metastasis of oral squamous cell carcinoma by up-regulating SOD2/H2O2 signaling pathway (10, 11). This evidence concerns the gene PKM and oral cavity squamous cell carcinoma.