CXCL12 and acute myeloid leukemia: Based on the important roles of SDF-1α/CXCR4 signaling in AML chemotherapy resistance, a previous study showed that inhibition of CXCR4 disrupted the SDF-1α/CXCR4 signaling pathway, which plays a crucial role in protecting AML cells from chemotherapy-induced apoptosis by mediating their interaction with the bone marrow microenvironment (21).