Congruently, inhibition of PGC-1α promotes hepatic inflammation in mice fed a high-fat diet by activating the IκBα-NFκB pathway [7], although other studies reveal that PGC-1α regulates the insulin signaling pathway and contributes to the development of NAFLD via increasing inflammation and oxidative damage [8, 9]. The gene discussed is PPARGC1A; the disease is metabolic dysfunction-associated steatotic liver disease.