PPARGC1A and metabolic dysfunction-associated steatohepatitis: To investigate whether PGC-1α participates in NASH progress, we first analyzed the public-available microarray data derived from four independent studies of liver specimens of healthy controls and NASH patients (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE17470, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE24807, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159676, and https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE164760).