SIRT2 and metabolic dysfunction-associated steatohepatitis: By surveying the expression of sirtuins in the GEO databases (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE164760, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE96936, and https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE35961), we identified a conserved down-regulation of SIRT2 in both NASH patients and mouse models (Fig. 4A).