These studies validate that the PGC-1α transcriptional levels are significantly reduced than healthy controls (Fig. 1A), as per the analyses provided in GEO2R in the Gene Expression Omnibus (GEO) database, suggesting that boosting the PGC-1α expression is potentially feasible to intervene NASH. The gene discussed is PPARGC1A; the disease is metabolic dysfunction-associated steatohepatitis.