SQSTM1 and amyotrophic lateral sclerosis: Importantly, TOI degradation does not require the UBA domain of p62 responsible for ubiquitin binding, which indicates that AUTOTAC may be applicable to pathologies where the ubiquitin-binding function of p62 is disturbed, as observed in some cases of Paget disease of bone [260] and amyotrophic lateral sclerosis/ALS [261].