SHOC2 and liver cancer: We further detected the SHOC2 levels, along with the basal status of the MAPK and mTORC signals, in nine human liver cancer cell lines and one normal liver cells LO2, and found that SHOC2 levels were relatively lower in Bel-7402 and RLC/PRF/5 cells, but relatively higher in HepG2, Hep3B and Huh7 cells (Fig. S1A).