SHOC2 and hepatocellular carcinoma: To investigate the possible role of SHOC2 in human liver cancer, we first searched the Cancer Genome Atlas (TCGA) database, and systematically analyzed the mRNA expression of SHOC2 between hepatocellular carcinoma (LIHC) and normal liver tissues, and found that SHOC2 is significantly overexpressed in cancer tissues (Fig. 1A).