TRPC3 and fatty liver disease: In an attempt to explore the mechanism by which TRPC3 knockdown aggravated hepatic steatosis in ALD, our data uncovered that TRPC3 deficiency was associated with AMPK suppression in mouse liver, evidenced by decreased protein abundance of p-AMPK and its down-stream target, p-ACC (Fig. 9a; Supplementary Fig. S18).