Cancer cells with high iron metabolism or low antioxidant defenses are particularly susceptible to ferroptosis, as the excessive iron load contributes to lethal levels of lipid peroxidation when GPX4 is suppressed more, the activation of ferroptosis pathways has been shown to counteract the survival mechanisms of apoptosis-resistant cancers, positioning it as a unique target in oncology. This evidence concerns the gene GPX4 and cancer.