Ourfindings demonstrate that PPWQ enhances the efficacy of RT througha dual mechanism/W6+ generate ROS, inducing extensive DNAdamage in tumor cells, while QR suppresses CD36 expression, therebyreducing fatty acid uptake and mitigating CD47-mediated immune evasion.This strategy disrupts tumor metabolic pathways essential for DNArepair and simultaneously reprograms the TME to bolster antitumorimmunity. The gene discussed is CD47; the disease is neoplasm.