MTOR and progeroid syndrome: In this regard, some compounds with the ability to induce progeria degradation through autophagy activation have been previously identified, including rapamycin (inhibitor of mTOR pathway) (Graziotto et al. 2012), MG132 (proteasome inhibitor) (Harhouri et al. 2017), sulforaphane (antioxidant compound) (Gabriel et al. 2015) and neuropeptide Y (Aveleira et al. 2020).