MAPT and Alzheimer disease: Many studies have reported that dysfunction of neuronal mitochondria, release of neuroinflammatory cytokines and reactive oxygen species (ROS), and toxicities of soluble Aβ or tau proteins have contributed to synaptic loss in AD patients (Baik et al. 2019; Kent, Spires‐Jones, and Durrant 2020; Merlini et al. 2019).