To determine the possible involvement of microglial Tmem9 in the regulation of synaptic dysfunction in AD model mice, as well as PE‐associated protection of synapses, we injected AAV containing a F4/80 promoter (Wang, Wang, et al. 2024) to overexpress microglial Tmem9 in PE‐5xFAD mice. Here, TMEM9 is linked to Alzheimer disease.