TP53 and central nervous system cancer: Additionally, p53 interacts with the transcription factor NF-Y, enhancing the ZDHHC5-mediated palmitoylation of EZH2 [307] Palmitoylated EZH2 inhibits the binding of DNMT3A to the OCT4 promoter, thereby reducing its methylation and promoting the overexpression of OCT4, which in turn accelerates glioma progression [307].