ABCA7 and Alzheimer disease: To investigate the impact of the deletion of the humanized ABCA7 transporter in our AD model, we analyzed the brain proteome of chimeric APPPS1-hA7ko (n = 8 males, 7 females) and APPPS1 mice carrying the wild-type mouse Abca7 gene (n = 7 males, 7 females) from 50 to 200 days of age by LC‒MS/MS (DDA).