More specifically, the Case exhibited lower frequencies of clusters representing activated CD4+ T lymphocytes (T4) like T4 TE (CD45RA− CD45RO+), T4 Th-17 like (CXCR3− CCR6+ CXCR5− CCR4+), T4 CM (CCR7+ CD45RA− CD45RO+) as well as lower frequencies of clusters representing activated CD8+ T lymphocytes (T8), like T8 TE (CCR7−CD45RA−CD45RO+) and T8 Eff CD161hi (high expression of killer cell lectin-like receptor subfamily B, member 1, KLRB1, CD161) compared to SLE patients and HCs. This evidence concerns the gene CD8A and systemic lupus erythematosus.