MAPT and Alzheimer disease: In addition to senile plaques and neurofibrillary tangles, a third pathological hallmark in AD brain tissue, “adipose inclusions” or “lipoid granules”, was described in Dr. Alois Alzheimer’s original report of AD in 1907 [33], this early suggestion of aberrant lipid metabolism has largely remained understudied over the past century, partially due to limited techniques for pursuing this direction, as well as the intensive focus on other disease hypotheses (such as Aβ and tau).