GO BP analysis showed that goblet cells from Lpr mice intestines enriched the terms related to inflammatory pathways such as response to interferon-gamma, positive regulation of cytokine production, and regulation of cytokine production involved in immune response (Supplementary Fig. 8D, Supplementary Table 17), suggesting a functional alteration of goblet cells in the context of lupus. Here, IFNG is linked to systemic lupus erythematosus.