Compared to the control group, the absolute numbers of CD45+CD8+ cells in the tumor, normalized by tumor weight, were significantly higher in the chemo > STING/α-PD-1 + α-CTLA-4 and chemo > NLRP3/α-PD-1 + α-CTLA-4 groups, with an increase exceeding 10-fold. The gene discussed is CD8A; the disease is neoplasm.