Given the prior finding that Stx2 is delivered by monocytes, we hypothesized that depleting monocytes by anti-CD14 neutralization antibody might block the transport of Stx2 to the kidney and thus attenuate the renal damage in the LPS/Stx2-induced murine HUS model (Fig. 5b) [17]. The gene discussed is STX2; the disease is hemolytic-uremic syndrome.