SCN1A and familial hemiplegic migraine: Four of the FHM mouse models carry mutations which cause in humans typical FHM attacks without additional clinical features (pure FHM): the R192Q mutation in the CaV2.1 channel [55], the W887R mutation and the E700K mutation in the α2 Na/K ATPase [57, 61] and the L1649Q mutation in the NaV1.1 channel [60].