For instance, the increase of glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) release by gut epithelium associated with Roux-en-Y gastric bypass (GB) and other procedures that exclude the duodenum from the passage of food is of utmost importance to improve glucose homeostasis and reduce insulin resistance 11. Here, GCG is linked to Insulin resistance.