This pathway is involved in the cell cycle, growth and proliferation, and implicated in the progression of various cancers.35 Interestingly, components that have a stimulatory effect on the pathway such as RPTOR, MTOR or MYC strongly correlate with each other and also demonstrate significant anticorrelation to inhibitory factors such as PTEN, TSC1 or TSC2. This evidence concerns the gene TSC1 and cancer.