BMAL1 and type 2 diabetes mellitus: Overexpression of Rev-erbα inhibited the activity of the Wnt/β-catenin pathway, while the expression trend of GSK-3β was similar to that of Rev-erbα.68 In GSK-3β knockdown mouse embryonic fibroblast cells, upregulation of Bmal1 expression was observed.69 Li et al. studied the relationship between GSK-3β, Bmal1, and the Wnt/β-catenin pathway in a model of type 2 diabetes-induced inhibition of BMSC osteogenesis.