SOST and osteoarthritis: For example, sclerostin is a crucial osteocyte-derived Wnt-β-catenin signaling antagonist, which can bind to the LRP-5/6 receptor and subsequently inhibit the Wnt–β-catenin pathway involved in bone metabolism.63 Loss of sclerostin promotes osteoarthritis in mice through Wnt-β-catenin signaling pathway.64 These key pathway regulators may become important targets for future research.