Huo et al. conditionally deleted Bmal1 in myeloid cells and resulted in enhanced vascular remodeling.180 Hong et al. indicated that myeloid selective Bmal1-knockout mice (Bmal1f/f, LysMcre/+) led to exacerbated hypometabolic state and these mice were more sensitive to LPS treatment, which were prone to suffer endotoxemia. Here, BMAL1 is linked to serum lipopolysaccharide activity.