FAP and cancer: In line with the pan-cancer results, we found in HDTVi HCC models (MYC_sgP53) with higher Fib_Fap frequency exhibited greater Cd8_Pdcd1 abundance (Supplementary Fig. S8c‒e) and an impaired response to immunotherapy (Supplementary Fig. S8f), suggesting MYC_sgP53 may be a counterpart of inflammatory hubs in human tumor stroma and serve as a modeling system for further mechanistic study.