Although prior studies have suggested a correlation between Wnt/β-catenin signaling and immune exclusion, as well as a lack of response to immunotherapy89, recent studies have shown that some patients with Wnt activation can exhibit enrichment of activated CD8+ T cells39, and CTNNB1-mutant ICB responders may display enhanced anti-tumor immunity90, highlighting the complex role of Wnt activation in the immune landscape and treatment response. The gene discussed is CD8A; the disease is neoplasm.