FAP and neoplasm: Spatially, we identified CAF-FAP and CAF-C7 as the potential organizers of intratumoral and marginal stroma, respectively (Fig. 4e; Supplementary Fig. S4h), as CAF-FAP is enriched in FR‒ tumor core (P = 8.7E‒03) while CAF-C7 is specifically clustered at FR (P = 8.2E‒03).