STAT3 and neoplasm: Differential gene expression (DGE) and gene set enrichment analysis (GSEA) (Fig. 1j; Supplementary Fig. S1j and Table S1) showed that FR+ tumor tissue is enriched for pathways related to liver-specific metabolism (xenobiotic metabolism, fatty acid metabolism, and OXPHOS) and WNT/β-catenin signaling while FR‒ tumors showed upregulated pathways related to inflammation (IFN-γ pathway, TNF-α pathway), immune suppression (IL-6-JAK-STAT3 signaling), and epithelial-mesenchymal transition (EMT), largely consistent at both mRNA and protein levels.