Consistent with spatially confined ECM proteins identified by spatial proteomics (Fig. 2e), we also found FBLN5 and LTBP1 enriched in FR, TSKU enriched in TS_FR+, and CSTB, ANXA4, LGSAL3 enriched in TS_FR‒ (Fig. 3c), suggesting coherent activation of ECM remodeling in HCC stromal architecture at both RNA and proteomic levels. The gene discussed is FBLN5; the disease is hepatocellular carcinoma.