As expected, mTOR inhibition led to robust hypophosphorylation of 4E-BP1 in BxPC-3/Capan-1 PDAC cells and SW-620 CRC cells, indicating that mTOR is the major 4E-BP1 kinase in these cells (Figure 11D). The gene discussed is EIF4EBP1; the disease is colorectal carcinoma.