Notably, SMAPs restored 4E-BP1 expression in cells with profound repression of the protein (e.g., many PDAC and CRC cell lines; Figure 3, C, E, and F) and increased 4E-BP1 expression in cells with readily detectable basal levels of the protein (e.g., MiaPaCa-2, S2-013, SNG-M, LoVo; Figure 3, C–F). The gene discussed is EIF4EBP1; the disease is colorectal carcinoma.