By leveraging novel small-molecule activators of PP2A with selectivity for a subset of PP2A heterotrimers (26, 30, 31), this study shows that B56-PP2A(s) orchestrate a translation-repressive program in tumor cells involving transcriptional upregulation of 4E-BP1 and dephosphorylation of 4E-BP1 and 4E-BP2 (Figure 14). The gene discussed is PTPA; the disease is neoplasm.