Remarkably, SMAPs/B56-PP2A can restore translational control in tumor cells with profound suppression of 4E-BP1 expression (e.g., many PDAC and CRC cell lines) by engaging a TFE3/TFEB→ATF4→4E-BP1 transcriptional axis (Figure 14). Here, EIF4EBP1 is linked to colorectal carcinoma.