It has been shown that AMP-actived protein kinase (AMPK) and mammalian target of rapamycin (mTOR) are two important kinases that induce and regulate autophagy, and affect autophagy by altering the activity of Unc-51-like autophagy activating kinase (ULK), thus affecting the progression of kidney disease [17–20]. This evidence concerns the gene MTOR and kidney disorder.