Additionally, ARNI reduced pulmonary pressures, vascular remodeling, and right ventricular hypertrophy in a rat model of pulmonary hypertension induced by SU5416/hypoxia model (Clements et al. 2019) and ameliorated hypoxia-induced pulmonary hypertension by suppressing apoptosis, inhibiting the inflammatory response, and inhibiting the PI3K/AKT signaling pathway (Wang et al. 2023b). The gene discussed is AKT1; the disease is pulmonary arterial hypertension.