CXCL12 and infection: These include the need for invasive surgical procedures for cell harvesting and implantation,[29] potential risks of pathogen transmission‐induced severe infection during transplantation, substantial financial costs related to cell isolation and culture,[3] and various risks associated with long‐term cell culture, such as genetic instability or contamination.[30] By contrast, the novel HG‐AA1:1‐SDF‐1α composite hydrogel developed in this study facilitated the efficient migration of endogenous MSCs to bone injured sites.