YAP1 and obesity due to melanocortin 4 receptor deficiency: Understanding the mechanism of YAP upregulation in obesity is critical due to its complex regulation by various post‐translational modifications, including phosphorylation, ubiquitylation, SUMOylation, acetylation, and O‐GlcNAcylation.[53, 54] These modifications intricately control YAP's stability, localization, and transcriptional activity.