Treatment with the OGT inhibitor OSMI‐1 significantly reduced tumor growth and tumor weight in HFD‐fed mice, consistent with the results observed in the 4T1‐BALB/c model (Figure S9E,F, Supporting Information).To determine if the HBP‐OGT‐EIF3H‐YAP axis plays a role in promoting TNBC metastasis, we utilized a spontaneous lung metastasis model by injecting 4T1 cells into the tail vein of BALB/c mice. This evidence concerns the gene YAP1 and neoplasm.