While the c‐Jun N‐terminal kinases (JNK) and mitogen‐activated protein kinase (MAPK) pathways also exhibit distinct activation patterns between the normal and obese groups, as observed in our ssGSEA analysis (Figure 1H), our study primarily focuses on the Hippo‐YAP signaling pathway due to its significant alteration and its direct involvement in obesity‐driven tumor progression. Here, MAPK8 is linked to obesity due to melanocortin 4 receptor deficiency.