YTHDF2 and Epstein-Barr virus infection: In line with the notion that m6A methylation appears to promote latent EBV infection and suppresses lytic EBV infection, a recent study uncovered that SUMOylation of YTHDF2 correlates with enhanced degradation of lytic viral transcripts and that transfection of YTHDF2 and the ligase responsible for its SUMOylation leads to reduced viral DNA copies upon EBV reactivation in HEK293T cells (64).