METTL3 and infection: While Wang et al. observed increased m6A levels due to METTL3 upregulation upon HSV-1 infection (74) and Feng et al. observed both hyper- and hypomethylation of transcripts in HSV-1-infected cells (75), Jansens et al. showed that infection of epithelial cell lines with either HSV-1 or PRV leads to a significant loss of m6A levels in total mRNA (38).