Knockdown of YTHDF1 via siRNA or reduction of SUMOylation of YTHDF1 or YTHDF3 by mutation of the SUMOylation sites during EBV reactivation in CNE2EBV cells (EBV-carrying poorly differentiated nasopharyngeal carcinoma cells) and Akata cells results in increased virus production (58, 64). The gene discussed is YTHDF1; the disease is nasopharyngeal carcinoma.