The inverse variance weighted test showed that protein arginine N-methyltransferase 3 (PRMT3) was positively related to CRC (b = 0.2024, P = 0.0071), and rs16892766 and rs355528 were the key single nucleotide polymorphisms (SNPs) (Fig. 8A and B). Here, PRMT3 is linked to colorectal carcinoma.