While low levels of 18F‐Flortaucipir uptake have been related to non‐specific neurodegeneration, including semantic dementia associated with TDP‐43 pathology, the neurodegenerative pattern here seems more aligned with the distribution of tau pathology rather than other MTL processes, such as limbic‐predominant age‐related TDP‐43 encephalopathy (LATE),45, 46 which has been described to be associated with more severe atrophy in anterior hippocampal relative to AD‐related tau.47 Here, TARDBP is linked to semantic dementia.