Compared to the HCs, patients with NPSs on the AD continuum were older (p < 0.001), had a lower frequency of female participants (p = 0.041), educational levels, and SES scores (both p’s < 0.001), a higher frequency of a history of hypertension (p = 0.007) and APOE ε4 carriers (p = 0.010), and lower folic acid levels (p = 0.038). Here, APOE is linked to Alzheimer disease.