Compared with mice in the ADSD group, those in the ADMD group showed less moving distance in the central area during the OFT (p = 0.004), increased immobility time in the TST (p = 0.046), decreased sucrose‐preference values (p = 0.043), and decreased time spent floating (p = 0.032) in the FST; similar findings were recorded only in the sucrose‐preference test in the WT mice (p = 0.007), suggesting malnourished diet‐induced depression‐ and anxiety‐like behaviors in the APP/PS1 mice. This evidence concerns the gene APP and depressive disorder.