Furthermore, our study also suggested the potential involvement of lower white matter integrity in the cingulum and SLF, which has been observed in cross-sectional studies of patients with AD (Zhao et al., 2021; Xiao et al., 2022) and has been suggested to serve as a significant predictor of worse visuomotor performance in APOE ε4 carriers (Rogojin et al., 2022). This evidence concerns the gene APOE and Alzheimer disease.